es5b02727_si_001.pdf (384.88 kB)
Comparison of the Toxicokinetics and Bioaccumulation Potential of Mercury and Polychlorinated Biphenyls in Goldfish (Carassius auratus)
journal contribution
posted on 2015-09-15, 00:00 authored by Jiajia Li, Ken G. Drouillard, Brian Branfireun, G. Douglas HaffnerBoth
mercury (Hg) and polychlorinated biphenyls (PCBs) demonstrate
food web biomagnification in aquatic ecosystems, yet their toxicokinetics
have not been simultaneously contrasted within a common fish species.
This study quantifies uptake and elimination rates of Hg and PCBs
in goldfish. Fish were exposed to contaminated food containing PCBs
and Hg to determine dietary chemical assimilation efficiencies (AEs)
and elimination coefficients (ktot). To
test first-order kinetics, three exposure regimes were established
by varying the proportion of contaminated fish incorporated into the
food. Dietary AEs were 98 ± 10, 75 ± 12, and 40 ± 9%
for MeHg, THg, and PCBs, respectively. The ktot values were 0.010 ± 0.003 and 0.010 ± 0.002 day–1 for THg and MeHg, respectively. No significant differences
were found in ktot among the dosing levels
for either THg or MeHg, confirming that Hg elimination is a first-order
process. For PCB, ktot ranged from 0.007
to 0.022 day–1 and decreased with an increase in
hydrophobicity. This study revealed that Hg had an AE higher than
that of PCBs, while the ktot of Hg was
similar to those measured for the most hydrophobic PCBs. We conclude
that Hg has a bioaccumulation potential in goldfish 118% higher than
the highest PCB BMF observed for congeners with a log KOW of >7.