Comparison of rotarod behavior indicates female-specific motor learning deficit.

(A) Both control and SAP97-cKO male animals show learning over the 4-day course of rotarod paradigm. Control female animals show increased motor learning over course of 4 days, while female SAP97-cKO show no significant increase in motor learning. (B) Plots showing comparison of Day 1 versus Day 4 rotarod data for control and SAP97-cKO animals indicates female-specific motor learning deficit. n.s., no significance, **P < .01, ***P < .001 (repeated-measures two-way ANOVA with Tukey’s test for multiple comparisons). Data are presented as mean ± SEM.