Comparison of protein topology graphs using graphlet-based methods

2013-10-28T21:45:17Z (GMT) by Tim Schäfer Tatiana Bakirova Ina Koch
<p>With the rapidly growing amount of protein structures available in public databases like the RCSB Protein Data Bank, there is a strong need for developing fast and accurate comparison methods for proteins. Detecting functional similarity, evolutionary relationships and/or structural motifs at different description levels of proteins is of major interest for many applications in biology and molecular medicine. Although there already exist different methods for protein structure alignment, the search of protein structure databases is still time consuming and similarity between proteins can be defined in many ways.</p> <p> </p>