ab5b00077_si_001.pdf (453.57 kB)
Coacervate Delivery of Growth Factors Combined with a Degradable Hydrogel Preserves Heart Function after Myocardial Infarction
journal contribution
posted on 2015-09-14, 00:00 authored by Noah Ray Johnson, Maritza Kruger, Kyle Peter Goetsch, Peter Zilla, Deon Bezuidenhout, Yadong Wang, Neil Hamer DaviesRegenerative
therapies to improve prognosis after heart attack
and mitigate the onset of heart failure are urgently needed. To this
end, we developed a bioactive therapy of sustained release of the
morphogen Sonic hedgehog (Shh) and the anti-inflammatory cytokine
interleukin-10 (IL-10) from a coacervate delivery vehicle. This is
combined with a structural therapy consisting of a biodegradable polyethylene
glycol (PEG) hydrogel, harnessing the benefits of both components.
Upon injection into the hearts of rats after heart attack, we found
that each component synergistically improved the benefit of the other.
Furthermore, their combination was critical to preserve heart function.
These findings indicate that, when combined, growth factor delivery
and an injectable hydrogel represent a promising therapeutic approach
for treatment after heart attack.