Fig 3.TIF (1.21 MB)
Cladogram of unc-29 copies.
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posted on 2016-07-14, 11:49 authored by Thomas B. Duguet, Claude L. Charvet, Sean G. Forrester, Claudia M. Wever, Joseph A. Dent, Cedric Neveu, Robin N. BeechThis phylogeny was used to develop codon substitution models that produced the data in Table 1. Branches within the Strongyloidea, leading to the different genes are labelled A-J. Branches leading to paralogous copies are labelled yellow, those corresponding to orthologs in different species are labelled blue. See Fig 1 for species names.
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gene copiesreceptor assemblyanthelmintic drug targetsreceptors reconstitutedphenotype rescueCaenorhabditis eleganscodon substitution rate analysisacetylcholine receptorssubunits co-expressedRecent DuplicationXenopus oocytesnematodeacetylcholine receptor subunit genesFunctional Divergencenovel drug targetssubunit duplicationfast-synaptic transmissionclade Vgenome dataHaemonchus contortusunc -29acetylcholine receptor subunitacid positions25 speciesreceptor composition changesubunit compositionParasitic Nematode Levamisole-Sensitive Acetylcholine Receptors Helminth parasitesgene duplicationsubunit assemblypentameric levamisole-sensitive acetylcholine receptor50 helminth genome initiative
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