Chiral Diene as the Ligand for the Synthesis of Axially Chiral Compounds via Palladium-Catalyzed Suzuki−Miyaura Coupling Reaction

The first palladium−diene-catalyzed asymmetric Suzuki−Miyaura coupling reaction has been achieved. A number of functionalized biaryls were obtained in high yields and in moderate to high enantioselectivities. The existence of an <i>ortho</i>-formyl group greatly improves the catalyst efficiency and permits further synthetic elaborations.