ol6b02816_si_003.cif (384.67 kB)
Chiral Aryliodine-Mediated Enantioselective Organocatalytic Spirocyclization: Synthesis of Spirofurooxindoles via Cascade Oxidative C–O and C–C Bond Formation
dataset
posted on 2016-10-21, 19:48 authored by Yang Cao, Xiang Zhang, Guangyu Lin, Daisy Zhang-Negrerie, Yunfei DuAn
enantioselective organocatalytic oxidative spirocyclization
of alkyl 3-oxopentanedioate monoamide derivatives leading to the formation
of diverse spirofurooxindoles with high enantioselectivity has been
realized via chiral aryliodine-mediated cascade C–O and C–C
bond formations. The reaction is postulated to proceed via oxidative
C–O bond formation followed by oxidative C–C bond formation,
with the latter being the enantioselectivity-determining step.
