Chemistry of new dimethyl-benzo,-1,3,6-oxadiazepine and 1,3,5-triazepine derivatives as anticancer agents

2017-11-30T21:31:46Z (GMT) by Ameen Ali Abu-Hashem Ahmed S. Aly
<p>A series of novel substituted 2,4-dimethyl-benzo[f][1,3,5] triazepine, such as 2-thioxopyrimidinone(4), 2-oxopyridine-3-carbonitrile(6), benzamide(8), <i>N’-</i>(6-oxopyrimidine)benzohydrazide(10), 1-(4-(1,3,4-oxadiazole)thiophene)ethan-one(12), 1-(4-methylthiophene-3-carbonyl)pyrazolidine-dione(14), 1-(4-(pyrazole-carbonyl)-3-methylthiophene)ethanone(16), ethyl dimethylthieno[2,3-<i>b</i>]pyridine-2-carboxylate (18), and 2-thioxo-thieno[2,3-<i>d</i>]pyrimidinone(20) derivatives, were synthesized from 2,4-dimethyl benzo[<i>d</i>] [1,3,6] oxadiazepine (2). The structures of these newly synthesized compounds were established on the basis of their spectral data and elemental analysis. These compounds were also screened for their anti-tumor activities. Some of the prepared compounds showed promising activities for example; benzotriazepine, thienopyrimidine, oxadiazole, and thiophene moiety displayed cytotoxic activity.</p>