Chemical constituents from <i>Curcuma longa</i> L. and their inhibitory effects of nitric oxide production

<p>A new bisabolane-type sesquiterpenoid, turmerone Q (<b>1</b>), along with six known compounds (<b>2–7</b>), were isolated from the rhizomes of <i>Curcuma longa</i> L. The structural elucidation of the new compound was conducted using <sup>1</sup>H NMR, <sup>13</sup>C NMR, HSQC, HMBC and NOESY spectroscopic analyses. The absolute configuration of <b>1</b> was elucidated by comparison of the experimental and calculated ECD spectra. The anti-inflammatory effects of <b>1–7</b> were evaluated through lipopolysaccharide-induced nitric oxide (NO) production in RAW 264.7 macrophages assays, and compounds <b>6</b> and <b>7</b> showed potent inhibitory activity against NO production.</p>