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Chemical constituents from Curcuma longa L. and their inhibitory effects of nitric oxide production

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posted on 2017-07-20, 14:11 authored by Ting Yuan, Cuiyun Zhang, Chongyue Qiu, Guiyang Xia, Fei Wang, Bin Lin, Hua Li, Lixia Chen

A new bisabolane-type sesquiterpenoid, turmerone Q (1), along with six known compounds (2–7), were isolated from the rhizomes of Curcuma longa L. The structural elucidation of the new compound was conducted using 1H NMR, 13C NMR, HSQC, HMBC and NOESY spectroscopic analyses. The absolute configuration of 1 was elucidated by comparison of the experimental and calculated ECD spectra. The anti-inflammatory effects of 1–7 were evaluated through lipopolysaccharide-induced nitric oxide (NO) production in RAW 264.7 macrophages assays, and compounds 6 and 7 showed potent inhibitory activity against NO production.

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