Chemical composition, antioxidant, antibacterial and cytotoxic activities of essential oil of <i>Leontopodium leontopodioides</i> (Willd.) Beauverd

<p>The essential oil (EO) from the aerial parts of <i>Leontopodium leontopodioides</i> (Willd.) Beauverd was obtained by hydrodistillation and analysed by GC–FID and GC–MS. Sixty-five compounds were identified which represent 96.2% of the total composition of the EO. The major components of the EO were palmitic acid (11.6%), <i>n</i>-pentadecanal (5.7%), linalool (3.8%), <i>β</i>-ionone (3.3%), hexahydrofarnesyl acetone (3.2%), bisabolone (3.2%) and <i>β</i>-caryophyllene (3.2%). The EO exhibited an excellent antibacterial activity against <i>Staphylococcus aureus</i> and <i>Bacillus subtilis</i> according to the MIC values tested by micro-dilution method. It also exhibited a significant cytotoxicity against HepG2 and MCF-7 cell lines with the IC<sub>50</sub> values of 67.44 and 70.49 μg/mL according to the MTT assay. However, the antioxidant activity test revealed that the EO exhibited a weak DPPH radical-scavenging activity. In conclusion, the EO of <i>L. leontopodioides</i> could be regarded as a bioactive natural product and deserves further study for its potential therapeutic effects.</p>