Characterization and antibacterial activity of PVA–PVP–CS carvacrol-loaded polymer composite films for urinary catheter

<p>The formation of biofilm over the urinary catheter leading to CAUTI remains an unresolved major cause of bacteremia in hospital patients. In-order to find an alternative, feasible solution we developed a new potential composite film containing polyvinyl alcohol, polyvinylpyrrolidone, and chitosan by solvent evaporation technique. The developed composite film was loaded with carvacrol (CAV), a naturally occurring broad-spectrum antimicrobial agent and was characterized. The CAV-loaded film exhibited appreciable growth inhibition, resistance to biofilm formation, and microbial penetration of infectious bacterial strains isolated from hospital such as <i>Escherichia coli, Bacillus subtilis,</i> and <i>Salmonella typhimurium</i>. Thus, the developed CAV-loaded polymer composite film can serve as a potential alternative biomaterial for developing biofilm formation-resistant urinary catheter.</p>