Fig 5.tif (914.95 kB)
Celiac Subsequence Matrix.
figure
posted on 2016-01-29, 09:19 authored by Rok Seon Choung, Eric V. Marietta, Carol T. Van Dyke, Tricia L. Brantner, John Rajasekaran, Pankaj J. Pasricha, Tianhao Wang, Kang Bei, Karthik Krishna, Hari K. Krishnamurthy, Melissa R. Snyder, Vasanth Jayaraman, Joseph A. MurrayThe 3-mer subsequences with maximum occurrences among sequences with high sensitivity and specificity for among IgG and IgA reactivity were determined, and the best combinations of subsequences were plotted as a matrix table. The nine 3-mers with the highest score were combined in each possible iteration of two 3-mers to form 81 6-mer sequences, with N-terminal sub-sequences listed in the column, and the C-terminal sub-sequences listed in the row. A) IgG 3-mer subsequences, maximum occurrences. B) IgA 3-mer subsequences, maximum occurrences. % implies any number of amino acid(s) present prior to the subsequence portion of the sequence. For example, ‘%QPE’ could be WALLTYQPE while ‘%QPE%’ could be WAQPELLTY.
