Catalytic Formation of Silyl Enol Ethers and Its Applications for Aldol-Type Condensation and Aminomethylation Reactions

2011-05-06T00:00:00Z (GMT) by Ruili Gao Chae S. Yi
A new catalytic method for the synthesis of silyl enol ethers has been developed from the coupling reaction of ketones with CH<sub>2</sub>CHSiMe<sub>3</sub> by using a ruthenium hydride catalyst (PCy<sub>3</sub>)<sub>2</sub>(CO)RuHCl. The synthetic utility of silyl enol ethers was demonstrated for both Mukaiyama aldol condensation and aminomethylation reactions in forming β-hydroxyketones and β-aminoketones, respectively.