lsyc_a_1525740_sm5375.pdf (2.37 MB)
Catalyst-free synthesis of 3-substituted-3-hydroxy-2-oxindoles by reaction of isatin and cyclic enaminone in water
journal contribution
posted on 2018-11-08, 10:51 authored by Keshri Nath Tiwari, Snehal Rajendra Thakar, Vaneet Kumar, S. M. PrabhakaranAn easy protocol for the synthesis of enaminone attached 3-substituted-3-hydroxy-2-oxindoles has been demonstrated by reaction of isatin and cyclic enaminone in water. The developed catalyst-free reaction has the advantage of being atom-economical, eco-friendly, and benign reaction conditions. The broader substrate scope, experimentally simple procedures, and easy purification of products with high yield further make this method attractive and useful.