CatB deficiency reduced while cystatin C deficiency increased myocardial pyroptosis caused by CVB3 inoculation.

(A) Representative cardiac TUNEL staining of mice with different treatments. Scale bar: 50μm. (B) The statistical result showed the increased TUNEL positive staining cells in the WT+CVB3 group were significantly decreased in the Ctsb^-/-+CVB3 group, but further increased in the Cstc^-/-+CVB3 group. (WT group: n = 10; WT+CVB3 group: n = 14; Ctsb^-/-+CVB3 group: n = 12; Cstc^-/-+CVB3 group: n = 11; ***P<0.001 vs. WT group; ##P<0.01 vs. WT+CVB3 group; &&&P<0.001 vs. Ctsb^-/-+CVB3 group).