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Caloinophyllin A, a new chromanone derivative from Calophyllum inophyllum roots

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posted on 2018-01-19, 12:45 authored by Sasa Ponguschariyagul, Jirapast Sichaem, Suttira Khumkratok, Pongpun Siripong, Kiattisak Lugsanangarm, Santi Tip-pyang

A new chromanone derivative, namely caloinophyllin A (1), along with eight known compounds (29), nobiletin (2), pentamethylquercetin (3), 3,5,7,4′-tetramethoxyflavone (4), 5,7,4′-trimethoxyflavone (5), 1,5-dihydroxyxanthone (6), 1,8-dimethoxy-2-hydroxyxanthone (7), 1,6-dihydroxy-7-methoxyxanthone (8) and 4-methoxycaffeic acid (9) were isolated from the roots of Calophyllum inophyllum. The structures of all the isolated compounds (19) were fully characterised using spectroscopic data, as well as comparison with the previous literature data. In addition, the quantum chemical calculation has been used to confirm the conformation of 1. Moreover, all isolated compounds were assessed for their in vitro cytotoxicity against five human cancer cell lines.

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