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Calibration of p-values produced by MAPIT via QQ-plots.

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posted on 2017-07-26, 17:56 authored by Lorin Crawford, Ping Zeng, Sayan Mukherjee, Xiang Zhou

The QQ-plots applying MAPIT to 100 simulated null datasets assuming sample sizes (A) 1,000, (B) 1,750, and (C) 2,500. Blue dots are p-values produced by under the normal test (or z-test), while the black dots represent p-values tested using the Davies method via a mixture of chi-square distributions. The 95% confidence intervals for the null hypothesis of no association are shown in grey.

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