CSF biomarker levels in control, congenital hydrocephalus, and other neurological diseases.

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posted on 2017-02-17, 18:53 authored by David D. Limbrick Jr., Brandon Baksh, Clinton D. Morgan, Gakwaya Habiyaremye, James P. McAllister II, Terrie E. Inder, Deanna Mercer, David M. Holtzman, Jennifer Strahle, Michael J. Wallendorf, Diego M. Morales

Box and whisker plots comparing normalized levels of CSF biomarkers measured in control, other neurological diseases (OND), and congenital hydrocephalus (CHC) subjects across all ages. Note the significant (*, p<0.05) increases in APP, Aβ₄₂, sAPPα, sAPPβ, L1CAM, NCAM-1, tau, and pTau in CHC compared to both control and OND cases.

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amyloid precursor protein NCAM CHC L 1CAM CSF sAPP α cut-point frontal-occipital horn ratio L 1CAM levels Logistic regression analysis Conclusions CSF proteins ELISA AUC CSF tau levels AQP TP Results CSF levels subject Cerebrospinal fluid biomarkers Methods CSF levels hydrocephalus Introduction Hydrocephalus

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CSF biomarker levels in control, congenital hydrocephalus, and other neurological diseases.

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