COX-2/PGE<sub>2</sub> regulates JAK2/STAT3 signaling in CRC cells.

<p>A. and B. Extracts from SW620 and LoVo cells transfected with COX-2 over-expression or shRNA construct were analyzed for pJAK2, JAK2, pSTAT3, STAT3, MMP-2, MMP-9 and beta-actin. C. and D. Extracts from SW620 and LoVo cells treated with PGE<sub>2</sub> for indicated durations were analyzed for pJAK2, JAK2, pSTAT3, STAT3, MMP-2, MMP-9 and beta-actin.</p>