jp6b04683_si_001.pdf (2.62 MB)
Boosting DNA Recognition Sensitivity of Graphene Nanogaps through Nitrogen Edge Functionalization
journal contribution
posted on 2016-08-05, 00:00 authored by Rodrigo G. Amorim, Alexandre R. Rocha, Ralph H. ScheicherOne
of the challenges for next generation DNA sequencing is to
have a robust, stable, and reproducible nanodevice. In this work,
we propose how to improve the sensing of DNA nucleobase using functionalized
graphene nanogap as a solid state device. Two types of edge functionalization,
namely, either hydrogen or nitrogen, were considered. We showed that,
independent of species involved in the edge passivation, the highest-to-lowest
order of the nucleobase transmissions is not altered, but the intensity
is affected by several orders of magnitude. Our results show that
nitrogen edge tends to p-dope graphene, and most importantly, it contributes
with resonance states close to the Fermi level, which can be associated
with the increased conductance. Finally, the translocation process
of nucleobases passing through the nanogap was also investigated by
varying their position from a certain height (from +3 to −3
Å) with respect to the graphene sheet to show that nitrogen-terminated
sheets have enhanced sensitivity, as moving the nucleobase by approximately
1 Å reduces the conductance by up to 3 orders of magnitude.
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edge passivationedge functionalizationresonance statesfunctionalized graphene nanogapnucleobase transmissionsresults showstate devicemagnitudeconductanceFermi levelBoosting DNA Recognition Sensitivity3 ordersgraphene sheetGraphene Nanogapstranslocation processDNA nucleobase1 Ånitrogen edgeNitrogen Edge Functionalizationgeneration DNA sequencing
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