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Bmi1 is essential for maintenance of KSHV latency.

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posted on 2018-09-13, 18:13 authored by Sharon E. Hopcraft, Samantha G. Pattenden, Lindsey I. James, Stephen Frye, Dirk P. Dittmer, Blossom Damania

BCBL-1 cells were mock transfected or transfected with control or Bmi1 siRNAs, and cells were lysed at 0 and 96 hours post-transfection. KSHV lytic proteins were assayed by immunoblot.

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    PLOS Pathogens

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    KaposiJQhistone deacetylase inhibitorssarcoma-associated herpesvirus reactivationlytic gene expressionB cell cancersPTCKSHV lytic gene transactivator RTAPrimary Effusion LymphomaBmiKSHV reactivationhost chromatin-modifying proteins

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