jo025705t_si_001.pdf (5.13 MB)
Biosynthesis of Terpenes. Preparation of (E)-1-Hydroxy-2-methyl-but-2-enyl 4-Diphosphate, an Intermediate of the Deoxyxylulose Phosphate Pathway†
journal contribution
posted on 2002-05-22, 00:00 authored by Sabine Amslinger, Klaus Kis, Stefan Hecht, Petra Adam, Felix Rohdich, Duilio Arigoni, Adelbert Bacher, Wolfgang Eisenreich(E)-1-Hydroxy-2-methyl-but-2-enyl 4-diphosphate (E-6) was synthesized in six reaction steps from
hydroxyacetone (9) and (ethoxycarbonylmethenyl)-triphenylphosphorane (11) with an overall yield
of 38%. The compound was shown to be identical with the product of IspG protein, which serves as
an intermediate in the nonmevalonate terpene biosynthetic pathway.