jm0209782_si_001.pdf (156.21 kB)
Biosynthesis of Hyperforin in Hypericum perforatum
journal contribution
posted on 2002-09-17, 00:00 authored by Petra Adam, Duilio Arigoni, Adelbert Bacher, Wolfgang EisenreichCut sprouts of Hypericum perforatum were proffered solutions containing [1-13C]glucose or
[U-13C6]glucose. Hyperforin was isolated and analyzed by quantitative NMR spectroscopy. The
labeling patterns show that the biosynthesis of hyperforin involves five isoprenoid moieties,
which are derived entirely or predominantly (>98%) via the deoxyxylulose phosphate pathway.
The phloroglucinol moiety is generated via a polyketide type mechanism.