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Bioionic Liquid Conjugation as Universal Approach To Engineer Hemostatic Bioadhesives
journal contribution
posted on 2019-10-13, 19:13 authored by Vaishali Krishnadoss, Atlee Melillo, Baishali Kanjilal, Tyler Hannah, Ethan Ellis, Andrew Kapetanakis, Joshua Hazelton, Janika San Roman, Arameh Masoumi, Jeroen Leijten, Iman NoshadiAdhesion to wet and
dynamic surfaces is vital for many biomedical
applications. However, the development of effective tissue adhesives
has been challenged by the required combination of properties, which
includes mechanical similarity to the native tissue, high adhesion
to wet surfaces, hemostatic properties, biodegradability, high biocompatibility,
and ease of use. In this study, we report a novel bioinspired design
with bioionic liquid (BIL) conjugated polymers to engineer multifunctional
highly sticky, biodegradable, biocompatible, and hemostatic adhesives.
Choline-based BIL is a structural precursor of the phospholipid bilayer
in the cell membrane. We show that the conjugation of choline molecules
to naturally derived polymers (i.e., gelatin) and synthetic polymers
(i.e., polyethylene glycol) significantly increases their adhesive
strength and hemostatic properties. Synthetic or natural polymers
and BILs were mixed at room temperature and cross-linked via visible
light photopolymerization to make hydrogels with tunable mechanical,
physical, adhesive, and hemostatic properties. The hydrogel adhesive
exhibits a close to 50% decrease in the total blood volume loss in
tail cut and liver laceration rat animal models compared to the control.
This technology platform for adhesives is expected to have further
reaching application vistas from tissue repair to wound dressings
and the attachment of flexible electronics.