Fig 3.tif (2.88 MB)
Biodistribution of process A and process B rhASA in rats.
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posted on 2018-04-19, 17:45 authored by Teresa Wright, Aiqun Li, Jason Lotterhand, Anne-Renee Graham, Yan Huang, Nancy Avila, Jing PanRepresentative whole body autoradioluminograms showing tissue distribution of radioactivity 4 hours after a single intrathecal dose of (A) process A and (B) process B [125I]-rhASA 0.62 mg in male Sprague Dawley rats. rhASA, recombinant human arylsulfatase A.
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nonclinical comparability programprocess B rhASAcynomolgus monkeysB rhASAimmunotolerant MLD micelysosomal-associated membrane proteinmanufacturing process changesimmunohistochemical stainingNonclinical comparability studiesB rhASA-dosed micemanufacturing process changes Recombinantprocess B rhASA-related toxicityManufacturing process changes
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