np7b00032_si_001.pdf (4.18 MB)
Bioactive Azaphilone Derivatives from the Fungus Talaromyces aculeatus
journal contribution
posted on 2017-07-27, 18:20 authored by Jie Ren, Shuang-Shuang Ding, Ao Zhu, Fei Cao, Hua-Jie ZhuSix new azaphilone derivatives, talaraculones
A–F (1–6), together with five
known analogues (7–11), were obtained
from the saline soil-derived fungus Talaromyces aculeatus. The absolute configurations of 1 and 6 were assigned by quantum chemical calculations of the electronic
circular dichroism (ECD) spectra. Compounds 1 and 5 represent the first reported azaphilone derivatives with
a C4 aliphatic side chain and a methylal group at C-3, respectively.
Talaraculones A and B (1 and 2) exhibited
stronger inhibitory activity against α-glucosidase than the
positive control acarbose (IC50 = 101.5 μM), with
IC50 values of 78.6 and 22.9 μM, respectively.
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saline soil-derived fungus Talaromyces aculeatusquantum chemical calculationsBioactive Azaphilone Derivatives101.5glucosidase78.6analogueazaphilone derivativesECD22.9 μ MmethylaldichroismIC 50 valuesTalaraculoneCompoundacarboseconfigurationtalaraculonespectraFungus Talaromyces aculeatusα-C 4 aliphatic side chain
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