Benzopyran derivatives from endophytic <i>Daldinia eschscholzii</i> JC-15 in <i>Dendrobium chrysotoxum</i> and their bioactivities

<p>Five new benzopyran derivatives (<b>2</b>–<b>6</b>) and a new natural product (<b>1</b>) were isolated from endophytic <i>Daldinia eschscholzii</i> in <i>Dendrobium chrysotoxum</i> and determined as (R)-2,3-dihydro-2,5-dihydroxy-2-methylchromen-4-one (<b>1</b>), (2R, 4S)-2,3-dihydro-2-methyl-benzopyran-4,5-diol (<b>2</b>), (R)-3-methoxyl-1-(2,6-dihydroxy phenyl)-butan-1-one (<b>3</b>), 7-O-α-d-ribosyl-5-hydroxy-2-methyl-4H-chromen-4-one (<b>4</b>), 7-O-α-d-ribosyl-2,3-dihydro-5-hydroxy-2-methyl-chromen-4-one (<b>5</b>), daldinium A (<b>6</b>). These compounds were evaluated for their antimicrobial activity, anti-acetylcholinesterase, nitric oxide inhibition, anticoagulant, photodynamic antimicrobial activities and glucose uptake of adipocytes. Some compounds showed photoactive antimicrobial activities and glucose uptake stimulating activities.</p>