jo5b00907_si_001.pdf (4.22 MB)
Base Mediated Synthesis of Alkyl-aryl Ethers from the Reaction of Aliphatic Alcohols and Unsymmetric Diaryliodonium Salts
journal contribution
posted on 2015-06-19, 00:00 authored by Sunil
K. Sundalam, David R. StuartThe
base mediated coupling of aliphatic alcohol pronucleophiles
with unsymmetric diaryliodonium salt electrophiles is described. This
metal-free reaction is operationally simple, proceeds at mild temperature,
and displays broad substrate scope to generate industrially important
alkyl-aryl ethers in moderate to excellent yield. The synthetic utility
of these reactions is demonstrated, and aspects of sustainability
are highlighted by the use of unsymmetric aryl(mesityl)iodonium arylating
reagents.