Base−Base Interactions in the Minor Groove of Double-Stranded DNA
2006-07-21T00:00:00Z (GMT) by
A method has been developed for the synthesis of bisheaded nucleosides with thymine and adenine base moieties. We have demonstrated that, when incorporated in oligonucleotides, extrahelical A−T base interactions are possible when the bisheaded nucleosides are positioned in opposite strands of the duplex and are separated from each other by one regular base pair.
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