figshare
Browse
jo052194c_si_002.pdf (270.37 kB)

Base−Base Interactions in the Minor Groove of Double-Stranded DNA

Download (270.37 kB)
journal contribution
posted on 2006-07-21, 00:00 authored by Tongfei Wu, Koen Nauwelaerts, Arthur Van Aerschot, Matheus Froeyen, Eveline Lescrinier, Piet Herdewijn
A method has been developed for the synthesis of bisheaded nucleosides with thymine and adenine base moieties. We have demonstrated that, when incorporated in oligonucleotides, extrahelical A−T base interactions are possible when the bisheaded nucleosides are positioned in opposite strands of the duplex and are separated from each other by one regular base pair.

History