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Axially Chiral Triazoloisoquinolin-3-ylidene Ligands in Gold(I)-Catalyzed Asymmetric Intermolecular (4 + 2) Cycloadditions of Allenamides and Dienes
journal contribution
posted on 2012-09-05, 00:00 authored by Javier Francos, Francisca Grande-Carmona, Hélio Faustino, Javier Iglesias-Sigüenza, Elena Díez, Isaac Alonso, Rosario Fernández, José M. Lassaletta, Fernando López, José L. MascareñasThe first highly enantioselective intermolecular (4 +
2) cycloaddition
between allenes and dienes is reported. The reaction provides good
yields of optically active cyclohexenes featuring diverse substitution
patterns and up to three stereocenters. Key to the success of the
process is the use of newly designed axially chiral N-heterocyclic carbene–gold catalysts.