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Asymmetric Allylation of Glycidols Mediated by Allyl Acetate via Iridium-Catalyzed Hydrogen Transfer

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journal contribution
posted on 2017-02-21, 20:14 authored by Seung Wook Kim, Wonchul Lee, Michael J. Krische
Glycidols prepared via Sharpless asymmetric epoxidation participate in asymmetric redox-neutral carbonyl allylation with good levels of catalyst-directed diastereoselectivity. Equally stereoselective allylations may be performed from the aldehyde oxidation level using 2-propanol as the terminal reductant. An epoxide ring-opening reaction using AlMe3-n-BuLi is used to prepare the propionate-based stereotetrad spanning C17–C23 of dictyostatin, illustrating how this method may be applied to polyketide construction.

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