jo6b01590_si_001.pdf (11.4 MB)
Asymmetric Allylation/RCM-Mediated Synthesis of Fluorinated Benzo-Fused Bicyclic Homoallylic Amines As Dihydronaphthalene Derivatives
journal contribution
posted on 2016-08-30, 00:00 authored by Daniel M. Sedgwick, Pablo Barrio, Antonio Simón, Raquel Román, Santos FusteroEnantiomerically
enriched fluorinated benzo-fused bicyclic homoallylic amines have
been synthesized through an asymmetric allylation/ring closing metathesis
(RCM) sequence. This sequence has been carried out using α-trifluoromethylstyrene
derivatives as key intermediates, synthesized by microwave radiation.
The great deactivating effect exerted by such substituents has been
brought to light by a comparative study.