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Association between MPO-463G > A polymorphism and chronic kidney disease: a meta-analysis

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journal contribution
posted on 2018-10-03, 08:06 authored by Jiaxuan Qin, Jinchun Xing, Wei Li, Kaiyan Zhang, Zhun Wu

Background/objective: Previous studies have shown that MPO -463G > A (rs2333227) might be associated with chronic kidney disease (CKD) susceptibility, but sample sizes of those studies are relatively small. Hence, we decided to perform a meta-analysis to evaluate the association.

Methods/main results: Two investigators search databases systematically and independently. Odds ratios and 95% confidence intervals were used to pool the effect size. Four articles with 618 cases and 932 controls in total were included in our meta-analysis.

Conclusions: MPO -463G > A was not associated with CKD susceptibility in recessive model and homozygote comparison. MPO -463G > A was associated with increased risk of CKD in allelic comparison, heterozygote comparison and dominant model, however, the results lacked stability. Owing to insufficient data, the association between MPO -463G > A and CKD cannot be fully confirmed.

Funding

This work was supported by The Science Fund founded by the First Affiliated Hospital of Xiamen University for Young Scholars (Project Number: XYY2016011; Recipient: Jiaxuan Qin) and Fujian Provincial Department of Science and Technology (Project Number: 2016D009; Recipient: Jinchun Xing).

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