Artocarmins G–M, Prenylated 4‑Chromenones from the Stems of Artocarpus rigida and Their Tyrosinase
Inhibitory Activities

T. T. Nguyen, Mai; Le, Tho H.; Nguyen, Hai X.; Dang, Phu H.; Do, Truong N. V.; Abe, Manabu; Takagi, Ryukichi; Nguyen, Nhan T.

doi:10.1021/acs.jnatprod.7b00453.s001

np7b00453_si_001.pdf (6.35 MB)

Artocarmins G–M, Prenylated 4‑Chromenones from the Stems of Artocarpus rigida and Their Tyrosinase Inhibitory Activities

journal contribution

posted on 2017-12-11, 21:06 authored by Mai T. T. Nguyen, Tho H. Le, Hai X. Nguyen, Phu H. Dang, Truong N. V. Do, Manabu Abe, Ryukichi Takagi, Nhan T. Nguyen

Phytochemical analysis of an EtOAc extract of the stems of Artocarpus rigida led to the identification of seven new prenylated 4-chromenones, artocarmins G–M (1–7), and nine known compounds (8–17). Their structures were identified based on physical data analysis. In the tyrosinase inhibitory activity test, norartocarpetin (8) displayed the strongest effect, with an IC₅₀ value of 0.023 μM.