Aristololactam derivatives from the fruits of Aristolochia contorta Bunge

Three new aristololactam derivatives, aristololactam W–Y (1–3), and three known compounds (4–6) were isolated from the fruits of Aristolochia contorta Bunge. Compounds 1 and 2 represent the first example of an N-CH₂OCH₃ aristololactam derivative from natural products. Their structures were elucidated by 1D/2D NMR and HRESIMS spectra. All of the isolated compounds were evaluated for their insecticidal activity against 4th instar larvae of Aedes aegypti. Compound 4 displayed insecticidal activity with LC₅₀ value of 3.54 μg/mL.