jo902315t_si_001.pdf (3.77 MB)
Are sp Lithiated Carbons More Nucleophilic than sp2 or sp3 Ones? A Comparative DFT Study of the Condensation of Propynyllithium Aggregates on Formaldehyde
journal contribution
posted on 2010-03-05, 00:00 authored by Catherine Fressigné, Jacques MaddalunoThe interaction between 1-propynyllithium, taken as a model of sp organolithium compound, and formaldehyde has been investigated with DFT theoretical methods. The unsolvated monomer, homogeneous dimer, trimer, tetramer, and hexamer have been considered, as well as the mixed aggregates with lithium dimethylamide in various oligomeric forms. In most cases, the separate entities, their docking complexes, the transition states, and the condensation products have been characterized. Overall, the general reaction scheme remains the same whatever the hybridization and the aggregation. However, the dimeric sp nucleophiles are expected to be more reactive (at least in kinetic conditions), while monomeric sp3 entities would be the best nucleophiles in kinetic and thermodynamic conditions, even if its docking is the least exothermic. This work also suggests that the aggregation plays a relatively limited role on the model reaction.
History
Usage metrics
Categories
Keywords
monomeric sp 3 entitiesdocking complexessp Lithiated Carbonsmodel reactiondimeric sp nucleophilesFormaldehydeThe interactionreaction schemetransition statessp 3 Onescondensation productsunsolvated monomerlithium dimethylamidesp 2sp organolithium compoundPropynyllithium AggregatesComparative DFT Studyoligomeric forms
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC