ppat.1008263.g002.tif (7.45 MB)
Architecture of the outer regions of the basal body.
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posted on 2020-02-24, 18:49 authored by Michele Lunelli, Antje Kamprad, Jörg Bürger, Thorsten Mielke, Christian M. T. Spahn, Michael Kolbe(A) Composite map of the highest-resolution maps obtained for the outer regions of the needle complex (left panel), including the focused IM ring map with C24 symmetry, the connector map from the focused IM-connector reconstruction with C8 symmetry and the OM ring map from C1 reconstruction. The cyclic symmetry of the three regions is indicated on the left. (B) Atomic models of the corresponding needle complex proteins built using maps depicted in (A): MxiG (blue), MxiJ (orange) and MxiD (green).
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syringe-shaped protein translocation nanomachineHigh-resolution structuressecretin oligomerexport apparatus coreIM subunits bindcyclic symmetryβ- sheet augmentationperiplasmic N-terminal connector3.5 MDahelical architecturecryo-electron microscopy structuresecretin connectorType III Secretion Systemseffector translocationmembrane ringCryo-EM structureT 3SS needleextracellular needleinfection stagesT 3SShost cellseffector proteinsShigella T 3SS needlebasal bodymembrane-embedded basal bodyexport apparatus cagecryo-EM mapchannel systemShigella type III needle
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