figshare
Browse
lsyc_a_1348524_sm9648.docx (3.74 MB)

Aqueous single step synthesis and structural characterization of allylated, propargylated, and benzylated 3-substituted 3-aminooxindoles

Download (3.74 MB)
Version 2 2017-08-11, 14:21
Version 1 2017-07-10, 17:45
journal contribution
posted on 2017-08-11, 14:21 authored by Sameer A. Karpe, Man Singh, L. Raju Chowhan

Efficient zinc-mediated allylation, propargylation, and benzylation of isatin-derived imines were undertaken for the synthesis of 3-substituted 3-aminooxindoles with ≈80% yield. Such alternative approach has efficiently avoided the use of catalysts, severe reaction conditions, multistep procedures, and reaction additives. For exploring and materializing the synthetic utility, different allyl, propargyl, and benzyl bromides were used for generalizing the synthetic route. The structure of the synthesized compounds was established and confirmed by 1H NMR, 13C NMR, FTIR, and mass spectroscopic techniques.

History