ja401380d_si_001.pdf (17.83 MB)
Application of In Situ-Generated Rh-Bound Trimethylenemethane Variants to the Synthesis of 3,4-Fused Pyrroles
journal contribution
posted on 2013-03-27, 00:00 authored by Erica
E. Schultz, Richmond SarpongRh-bound trimethylenemethane
variants generated from the interaction
of a Rh-carbenoid with an allene have been applied to the synthesis
of substituted 3,4-fused pyrroles. The pyrrole products are useful
starting points for the syntheses of various dipyrromethene ligands.
Furthermore, the methodology has been applied to a synthesis of the
natural product cycloprodigiosin, which demonstrates antitumor and
immunosuppressor activity.