la205127x_si_001.pdf (79.45 kB)
Antiviral Properties of Polymeric Aziridine- and Biguanide-Modified Core–Shell Magnetic Nanoparticles
journal contribution
posted on 2012-03-06, 00:00 authored by Lev Bromberg, Daniel
J. Bromberg, T. Alan Hatton, Isabel Bandín, Angel Concheiro, Carmen Alvarez-LorenzoPolycationic superparamagnetic nanoparticles (∼150–250
nm) were evaluated as virucidal agents. The particles possess a core–shell
structure, with cores consisting of magnetite clusters and shells
of functional silica covalently bound to poly(hexamethylene biguanide)
(PHMBG), polyethyleneimine (PEI), or PEI terminated with aziridine
moieties. Aziridine was conjugated to the PEI shell through cationic
ring-opening polymerization. The nanometric core–shell particles
functionalized with biguanide or aziridine moieties are able to bind
and inactivate bacteriophage MS2, herpes simplex virus HSV-1, nonenveloped
infectious pancreatic necrosis virus (IPNV), and enveloped viral hemorrhagic
septicaemia virus (VHSV). The virus–particle complexes can
be efficiently removed from the aqueous milieu by simple magnetocollection.