Antioxidant and toxicological evaluation of a <i>Tamarindus indica</i> L. leaf fluid extract

<div><p>In the scientific community, there is a growing interest in <i>Tamarindus indica</i> L. leaves, both as a valuable nutrient and as a functional food. This paper focuses on exploring its safety and antioxidant properties. A tamarind leaf fluid extract (TFE) wholly characterised was evaluated for its anti-DPPH activity (IC<sub>50</sub> = 44.36 μg/mL) and its reducing power activity (IC<sub>50</sub> = 60.87 μg/mL). TFE also exhibited a high ferrous ion-chelating capacity, with an estimated binding constant of 1.085 mol L<sup>− 1</sup> while its influence over nitric oxide production in human leucocytes was irregular. At low concentrations, TFE stimulated NO output, but it significantly inhibited it when there was an increase in concentration. TFE was also classified as a non-toxic substance in two toxicity tests: the acute oral toxicity test and the oral mucous irritability test. Further toxicological assays are needed, although results so far suggest that TFE might become a functional dietary supplement.</p></div>