ppat.1006614.g005.tif (228.62 kB)
Antibody sensitivity of glycan-deleted variants of 16055 pseudovirus.
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posted on 2017-09-13, 17:48 authored by Viktoriya Dubrovskaya, Javier Guenaga, Natalia de Val, Richard Wilson, Yu Feng, Arlette Movsesyan, Gunilla B. Karlsson Hedestam, Andrew B. Ward, Richard T. WyattNeutralization IC50 values of the panel of bNAbs and mAbs are shown and color-coded for concentrations (μg/ml) regarding potency as indicated. NN = No Neutralization. These experiments were performed two independent times for the antibodies shown.
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16055 PNGS-deleted trimersHIV Env NFL trimer integrityCD 4 receptor engagementCD 4bsïve B cellswell-ordered clade C 16055CD 4bs bNAbsB cell repertoireresidue N 276rabbit immunogenicity experimentsB cell responsesantibodyglycosylated NFL trimersCD 4 binding siteglycosylated autologous virustier 2 virusesCD 4bs viruses4 PNGS sitesTargeted N-glycan deletionneutralizing determinantHIV envelope glycoproteinsN-glycan-deleted trimer variantsglycan-deleted trimer variantsB cell recognition
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