Antibacterial Effect of <i>2R</i>,<i>3R</i>-dihydromyricetin on the Cellular Functions of <i>Staphylococcus aureus</i>

<p>The C-3-OH, C-4 carbonyl oxygen and hydrogenation of C2=C3 bond on the C-ring of <i>2R</i>,<i>3R</i>-dihydromyricetin (DMY) proved to be not necessary for the antibacterial activity against <i>Staphylococcus aureus</i>. DMY significantly decreased the intracellular ATP of <i>S. aureus</i> cells but had few effects on pH<sub>in</sub>, proline oxidation, succinate dehydrogenase activity or malate dehydrogenase activity.</p>