Antiangiogenic phenylpropanoid glycosides from <i>Gynura cusimbua</i>

<p>A new phenylpropanoid glycoside, named <i>α</i>-L-rhamnopyranosyl-(1↔2)-<i>β</i>-D-[4″-(8<i>E</i>)-7-(3,4-dihydroxyphenyl)-8-propenoate, 1″-O-(7<i>S</i>)-7-(3,4-dihydroxyphenyl)-7-methoxy-ethyl]-glucopyranoside (<b>1</b>), together with nine known compounds (<b>2–10</b>) were isolated from the active fraction (<i>n</i><b>-</b>Butanol fraction) of <i>Gynura cusimbua</i> for the first time. The known compounds (<b>2–10</b>) were identified as phenylpropanoid glycosides on the basis of extensive spectral data and references. The antiangiogenic activities of compounds (<b>1–10</b>) were evaluated by MTT assay on HUVECs and wild-type zebrafish <i>in vivo</i> model assay. As a result, compounds <b>1</b>, <b>6</b>, <b>7</b>, <b>8</b> and <b>10</b> exhibited certain antiangiogenic activities.</p>