Anti-proliferative diterpenes from Dacrycarpus imbricatus

Tam, Nguyen Thanh; Quan, Tran Duc; Hau, Dang Viet; Anh, Nguyen Thi Hoang; Tran, Thi Thanh Thuy; Sa, Nguyen Hoang; Thien, Dao Duc; Le Thi Hong Nhung,; Phong, Dinh Thi; Adorisio, Sabrina; Delfino, Domenico V; Thuy, Trinh Thi

doi:10.6084/m9.figshare.6293159.v2

gnpl_a_1477149_sm0715.pdf (931.9 kB)

Anti-proliferative diterpenes from Dacrycarpus imbricatus

Version 2 2019-10-07, 12:24

Version 1 2018-05-21, 11:32

journal contribution

posted on 2019-10-07, 12:24 authored by Nguyen Thanh Tam, Tran Duc Quan, Dang Viet Hau, Nguyen Thi Hoang Anh, Thi Thanh Thuy Tran, Nguyen Hoang Sa, Dao Duc Thien, Le Thi Hong Nhung, Dinh Thi Phong, Sabrina Adorisio, Domenico V Delfino, Trinh Thi Thuy

A new diterpene, cassipouryl hexadecanoate (2), in addition to the cassipourol (1) and four terpenes (3–6) were isolated from the twigs and leaves of Dacrycarpus imbricatus (Blume) de Laub. The structures of the two monocyclic diterpenes (1, 2), were elucidated on the basic of 1D and 2D NMR spectroscopic data and compared with the literature. These two monocyclic diterpenes (1, 2) were tested for their anti-proliferative activity on acute myeloid leukemia (OCI-AML) cells. The results showed that 1 had significantly anti-proliferative activity whereas 2 was weakly active.