Anti-inflammatory and antiproliferative activities of Ixora brevifolia Benth. (Rubiaceae)

Medina, Rebeca P.; de Moura, Vagner M.; C. da Silva, Cleuza; de Oliveira, Cecília M. A.; Kato, Lucilia; Pomini, Armando M.; de Carvalho, João E.; Ruiz, Ana Lúcia T. G.; Bersani-Amado, Ciomar A.; Santin, Silvana M. O.

doi:10.6084/m9.figshare.5139739.v1

gnpl_a_1344654_sm7950.pdf (102.01 kB)

Anti-inflammatory and antiproliferative activities of Ixora brevifolia Benth. (Rubiaceae)

journal contribution

posted on 2017-06-23, 07:29 authored by Rebeca P. Medina, Vagner M. de Moura, Cleuza C. da Silva, Cecília M. A. de Oliveira, Lucilia Kato, Armando M. Pomini, João E. de Carvalho, Ana Lúcia T. G. Ruiz, Ciomar A. Bersani-Amado, Silvana M. O. Santin

The crude extract and fractions from the branches of Ixora brevifolia, a tree found in the Brazilian Cerrado, were tested for anti-inflammatory and in vitro antiproliferative effects. The crude extract and n-hexane fraction exhibited significant inhibition of ear oedema in mice, while n-hexane-precipitated and chloroform fractions strongly inhibited the myeloperoxidase activity in ear tissue. The n-hexane and n-hexane-precipitated fractions showed strong growth inhibition for glioma cell line and the hydromethanolic fraction inhibited the growth of leukaemia cell line.