Angiogenic response in virus-induced scars.

Endothelial CD31 expression (red) marks blood vessels, PDGFRα in green and lipid membranes in grey. (Left column, A, C, E, G, I, K) Overview, showing changes in vessel morphology and density in PDGF induced scars. (Right column, B, D, F, H, J, L) Asterisks mark big vessels with altered morphology. (M) Quantification of small vessels in the different experimental groups, normalized to the empty vector control. (N) Quantification of vessel size (area of cross-sectioned vessels) for the different experimental groups, normalized to the empty vector control. Analyses were performed on 3–4 mice per experimental group. E = empty vector; As = PDGF-A_short; Al = PDGF-A_long; B = PDGF-B; C = PDGF-C; D = PDGF-D. Scale bars are 100 μm.