lsyc_a_1528616_sm2481.doc (1.05 MB)
An efficient heterogeneous gold(I)-catalyzed hydration of haloalkynes leading to α-halomethyl ketones
journal contribution
posted on 2018-11-08, 10:56 authored by Sifan Hu, Dayi Liu, Chenyu Yan, Mingzhong CaiA highly efficient heterogeneous gold(I)-catalyzed hydration of haloalkynes has been developed that proceeds smoothly under mild and neutral conditions and provides a general and practical route for the synthesis of a variety of α-halomethyl ketones with high atom-economy, excellent yield, and recyclability of the gold(I) catalyst. The presented method delivers an attractive alternative to classical α-halogenation of ketones.