jo801172b_si_002.pdf (4.54 MB)
An Enantioselective Synthetic Route to cis-2,4-Disubstituted and 2,4-Bridged Piperidines
journal contribution
posted on 2008-09-05, 00:00 authored by Mercedes Amat, Maria Pérez, Annamaria T. Minaglia, Joan BoschA synthetic route to enantiopure cis-2,4-disubstituted and 2,4-bridged piperidines is reported, the key step being a stereoselective conjugate addition of an organocuprate to a phenylglycinol-derived unsaturated lactam bearing a substituent at the 8a-position.