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An Efficient Generation of a Functionalized Tertiary-Alkyl Radical for Copper-catalyzed Tertiary-Alkylative Mizoroki-Heck type Reaction
journal contribution
posted on 2013-11-06, 00:00 authored by Takashi Nishikata, Yushi Noda, Ryo Fujimoto, Tomomi Sakashitaα-Halocarbonyl
compounds undergo β-hydrogen elimination
to give conjugated olefins in the presence of a transition-metal catalyst.
However, a copper/triamine catalyst system can induce the alkylative
Mizoroki–Heck reaction of styrenes with tertiary-alkyl halides
possessing a withdrawing group under very mild conditions. This reaction
provides an efficient synthetic methodology for tertiary-alkylated
styrenes.